Every batch of sperm represents an opportunity for genetic typos - called de novo mutations - to be passed on. A 20-year-old man and woman will each pass on about 20 de novo mutations to a baby they conceive. By the time the couple is 40, a woman's t...
I work via the high-tension-wire method, which is maybe going for long periods without writing while the tension builds up - when am I going to write this, am I going to be able to write this, what is this image about - and I'm thinking about it all ...
The hardest part about writing fiction is finding long stretches of time to do it: for me, this means writing mostly on Saturdays and Sundays. But I am always thinking about my characters, jotting down ideas in stolen moments and hoping I'll be able ...
Let's say you need a perfectly obedient servant who never gets tired, never needs to be paid, and is virtually indestructible. If you're in a galaxy a long time ago and far, far away, you'll just fly off to the local droid auction and pick up one of ...
We really spend a lot of time on building relationships. And so when everyone is like, 'How do you break so many stories?' it's because I build relationships. I do it the old-fashioned way, and I build sourcing relationships, and then I take advantag...
I'm still getting used to the idea that people out in the world are reading my books. Every time I get a 'fan letter,' I am thrilled. But when people tell me that they're from the south or western Kentucky, and they say, 'I know exactly what you mean...
In terms of characters I wish I had created - just because I haven't dealt with anything like them - I'm really impressed by characters who can endure over time, whether that be a long series run like a Harry Bosch, or a character who endures over ge...
I think I had a particular moment when I was 15 years old. I read 'Crime and Punishment,' and that book just, I think, more than any other book made me want to be a writer, 'cause it was the first time that I hadn't just entered a book, but a book ha...
You know what works in venture capital? A group of incredibly smart, connected people who have the financial wherewithal and risk appetite to make multi-million dollar bets on unproven ideas and inexperienced founders. People who can make decisions q...
All of those broken bones in northern Japan, all of those broken lives and those broken homes prompt us to remember what in calmer times we are invariably minded to forget: the most stern and chilling of mantras, which holds, quite simply, that manki...
For almost every novel I've written, I've read the daily newspaper of the time almost as if it were my current subscription. For 'Two Moons,' which was set in 1877, I think I read just about every day of the 'Washington Evening Star' for that year. F...
My assumption when I began writing was that you were never going to make any money. And you were never going to reach everyone. Therefore you had to do as much as you could in the service of something you genuinely believed in. And if you do that and...
Fantasy sports went a long way toward developing the sabermetrics formulas used not only by oddsmakers but general managers in hiring players. So the amateur fantasists ended up creating some of the algorithms that Oakland GM Billy Bean's statisticia...
New York has arguably become the quintessential 1 percent city, a city that has been so given over to the rich that you now have to be rich to live here. Or not live here: New York's also a preferred destination for foreign money spent on vast, lifel...
It's rare that you have a policy issue that can be solved by throwing more money at the problem, but the technology to make bus service more frequent and equip buses with GPS systems that provide real-time schedule updates to bus stops exists and ope...
Actually, I never liked the idea of bags. I would say, 'Why do so many of my friends spend so much money on these bloody bags?' But once I started designing them, I was completely hooked. There are all of these blogs about bags. It's a whole other in...
When I was older and I first started working, I was obsessed with buying my first Chanel jacket. I saved up my hard-earned money, went to Barneys, and bought a little black Chanel jacket. It saw many, many job interviews and many, many events. I'm no...
Money and prices and markets don't give us exact information about how much our suburbs, freeways, and spandex cost. Instead, everything else is giving us accurate information: our beleaguered air and watersheds, our overworked soils, our decimated i...
I have long been one of those tedious people who rails against the coronation of 'student-athletes.' I have heard the argument that big-time athletics bring in loads of money to universities. I don't believe the money goes anywhere other than back in...
We live in a culture that's been hijacked by the management consultant ethos. We want everything boiled down to a Power Point slide. We want metrics and 'show me the numbers.' That runs counter to the immensely complex nature of so many social, econo...
When we run out of them upstairs, I've been known to appropriate some from our greenroom, pocketing a few with one hand as I smile and greet our guests with the other. One time, Dave Zinczenko of 'Eat this, Not That!' fame, busted me in the act. The ...
