I think the biggest problem in clinical trials is that they are underpowered. And that fundamentally, the studies are just too small.
My childhood wasn't very happy. It's a long, grim story about being a Jew in a small southern town.
At each small success we should not become our own heroes in our minds
Once you've been in space, you appreciate how small and fragile the Earth is.
My parents were ordinary people; we lived in a small apartment.
A deranged person is supposed to have the strength of ten men. I have the strength of one small boy... with polio.
It is not the greatness of a man's means that makes him independent, so much as the smallness of his wants.
If you think you are too small to be effective, you have never been in the dark with a mosquito!
The small amount of foolery wise men have makes a great show.
When I die cremate me so I can finally fit into something small.
As a little girl growing up in a small farming town in Michigan, my idols were women like Marlene Dietrich and Rita Hayworth.
And when you look at the sky you know you are looking at stars which are hundreds and thousands of light-years away from you. And some of the stars don’t even exist anymore because their light has taken so long to get to us that they are already de...
If we know our original blessing, we can easily handle our original sin. If we rest in a previous dignity, we can bear insults effortlessly. If you really know your name is on some eternal list, you can let go of the irritations on the small lists of...
I know this goes without saying, but Stonehenge really was the most incredible accomplishment. It took five hundred men just to pull each sarsen, plus a hundred more to dash around positioning the rollers. Just think about it for a minute. Can you im...
Something amazing happens when the rest of the world is sleeping. I am glued to my chair. I forget that I ever wanted to do anything but write. The crowded city, the crowded apartment, and the crowded calendar suddenly seem spacious. Three or four ho...
I'd encourage [you] to think big and be delusional when setting goals. Yes, delusional. The biggest mistake that I made with my first business was I didn't think big enough. I limited my success by just focusing on a small geographic area and focusin...
To whom shall I offer this book, young and sprightly, Neat, polished, wide-margined, and finished politely? To you, my Cornelius, whose learning pedantic, Has dared to set forth in three volumes gigantic The history of ages—ye gods, what a labor!�...
My life might have been so different, had I not been known as the girl whose grandmother exploded. And had I not been born in Bad Munstereifel. If we had lived in the city -- well, I"m not saying the event would have gone unnoticed, but the fuss woul...
1. We fear people because they can expose and humiliate us. 2. We fear people because they can reject, ridicule, or despise us. 3. We fear people because they can attack, oppress, or threaten us. These three reasons have one thing in common: they see...
It is pleasant to walk your dog beside a lake in winter in a tropical place because all of the black ducks waddle up the ryegrass bank and pluck the seed with their small gray beaks. There is nothing required of you but to watch them and wonder what ...
Have you been walking in the woods in the last few days?" Matt asked. Lola cleared her throat anxiously. What had she managed to do now, catch jungle fever? "We went hiking in the Greenhills on Wednesday. What's wrong?" Her voice sounded squeaky, so ...
