We must remember that one determined person can make a significant difference, and that a small group of determined people can change the course of history.
I could not tell you the date of my mother's death. I could not tell you the date of my dad's death. These are not dates that I find significant.
Death threatens our speech with futility because death is not just a biological event - it is a reality we fear may rob our living of any significance.
Making changes in the fast food that makes up such a significant part of the American diet, even if the numbers aren't impressive, will have important health up sides.
While pimples are not as simple as too much milk or sugar in your diet, both have a significant impact. Nutritional deficiencies as well as excesses can worsen acne.
Let it be your constant method to look into the design of people's actions, and see what they would be at, as often as it is practicable; and to make this custom the more significant, practice it first upon yourself.
In this view, the role of the great majority of Americans is simply to buy the products produced, work happily for their wages, and leave all of the significant economic decisions to the capitalists.
It may be easily shown, and is of no small significance, that the two great ideas of which the Anglo-Saxon is the exponent are having a fuller development in the United States than in Great Britain.
The participation of the people in their own government was the more significant, because the colonies actually had what England only seemed to have, - three departments of government.
When trying to remember my share in the glow of the eternal present, in the smile of God, I return to my childhood, too, for that is where the most significant discoveries turn up.
A significant number of pages and sentences that the administration wants to keep in a classified status have already been released publicly, some of it by public statements of the leadership of the CIA and the FBI.
We're involved right now in some very significant legal battles and it would be the wrong thing for me to do to step out in the middle of those battles.
Economists actually disagree about whether there are significant economic returns from attending an elite college versus a less-selective one.
If, as I have reason to believe, I have disintegrated the nucleus of the atom, this is of greater significance than the war. [ .]
Midlife is the time to let go of an overdominant ego and to contemplate the deeper significance of human existence.
I'm not naive enough to pretend that on its own cinema can capture the very soul of significant social and cultural problems.
Maintaining a consistent platform also helps improve product support - a significant problem in the software industry.
Fame is a by-product which you have to deal with in a sensible way. To believe that it is anything more significant than that is deeply self-deceptive.
Every person has a longing to be significant; to make a contribution; to be a part of something noble and purposeful.
There is no way the American public will sit still for the banning of or putting any significant restrictions on the kinds of guns they want.
Tech executives have historically been owners of significant portions of their companies' stock so there is a propensity for them to diversify as a rule.
