Science and religion both make claims about the fundamental workings of the universe. Although these claims are not a priori incompatible (we could imagine being brought to religious belief through scientific investigation), I will argue that in practice they diverge. If we believe that the methods of science can be used to discriminate between fundamental pictures of reality, we are led to a strictly materialist conception of the universe. While the details of modern cosmology are not a necessary part of this argument, they provide interesting clues as to how an ultimate picture may be constructed.