With drug use related harms, explanatory models are often presented as predictive tools, even though they ‘are [rarely if ever] predictive of consequent behavior’ or outcomes. Hence, we feel confident in asserting at outset, that prohibition based approaches in drug policy lack a sound basis in empirical research (despite sounding logical, i.e. remove drugs or the means of their production and less drugs will be available to users, thus minimising or eliminating harm), and are not animated by well-defined goals, goals that are not only consistent with the ethical and humanitarian aims of public health policy in general, but also with the fundamental principles of democracy) such as empowering or enabling those best placed to act, but by beliefs, assumptions, hypotheses and expectations.