Quote from : Star Wars: Episode III - Revenge of the Sith Movie

Darth Sidious: [Vader's new mechanical body arises from the steam] Lord Vader... can you hear me?
Darth Vader: Yes, Master.
Darth Vader: [Vader looks at Sidious] Where is Padme? Is she safe? Is she all right?
Darth Sidious: It seems in your anger, you killed her.
Darth Vader: I...? I couldn't have! She was alive... I felt it!
[Vader growls, and his Dark Side strength crushes everything around him in the room. He frees himself from the metal stretcher, and steps off. Palpatine has a smirk on his face]
Darth Vader: Nooooooooooooooooooo!