Quote from : Reading the Waste Land: Modernism and the Limits of Interpretation Book

In his 1923 review of James Joyce Ulysses, T. S. Eliot focused on one of his generation's recurrent anxieties--the idea that art might be impossible in the twentieth century. The reasons that art seemed impossible are many and complex, but they were all related to the collapse of ways of knowing that had served the Western mind at least since the Renaissance and that had received canonical formulation in the seventeenth century in the science of Newton and the philosophy of Descartes. In both science and philosophy, the crisis was essentially epistemological; that is, it was related to radical uncertainty about how we know what we know about the real world. This crisis, disorienting even to specialists, was at once a cause of despair and an incentive for innovation in the arts.